“When the U.S. military has to turn to fitness gurus like Tony Horton to help its soldiers slim down, you know obesity is a serious problem,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, “and all you have to do is visit to a nursing home to see the devastating effects of osteoporosis. “Sprouty” -well named- gets to the roots of extra fat and shrinking bone.”

To make this discovery, the researchers studied two groups of transgenic mice, one group with a genetic deletion of the Sprouty gene in cells that develop into fat and bone, and the second group with high levels of expressed Sprouty proteins in the same cell types. Results showed that the mice with the deleted Sprouty gene had increased body fat and loss of bone mass similar to osteoporosis as compared to normal mice. Bone loss was then reversed by adding more Sprouty protein. The group with excess Sprouty expression produced lean mice with increased bone mass.

“Our study provides insight into the regulation of bone mass and body fat,” said Lucy Liaw, Ph.D., co-author of the study from the Maine Medical Center Research Institute in Scarborough, ME. “Therefore, future application of this knowledge may help treat common conditions such as bone loss and obesity.”

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